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Prebiotics are a kind of non-digestible substances, which can be decomposed and utilized by gut microbiota

However, for deep pigmentation, such as melasma or darker skin tones, it is rarely enough by itself

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Therefore, we extracted and compared the metatranscriptome data annotated to Lachnospiraceae and Citrobacter (Fig

This has been attributed to increased mechanical fragility (iron deficient RBC are more rigid and more likely to fragment as they traverse through small capillaries under high shear), however oxidative injury to red blood cells is likely contributing to keratocyte formation (Yoo et al 2009) (given that antioxidant enzymes in red blood cells, such as glutathione peroxidase, contain iron)